Percent parasite motility by various synthetic inhibitors and GSK-J4.

Parasites were treated with indicated compounds at 1 μM for 48 hours. All experiments were repeated at least three times n = 3. Except for MSU-TSR-6-104 which is a structurally inactive analog and MSU-TSR-6-38, all compounds are selective towards adult parasitic stages. The compounds are also active against the closely related B. pahangi and the rodent nematode L. sigmodontis. All reported percent inhibition are within a ≤ 10% standard error. All compounds are inactive against C. elegans at 100 μM.