Epitranscriptomic map of N6-methyladenosine circular RNAs in the spinal cord of morphine-tolerant rats

Morphine tolerance is a tricky problem, the mechanism of it is still unclear. Circular RNAs (CircRNAs) play important roles in biological process of central nervous system. N6-methyladenosine (m6A) as a key post-transcriptional modification of RNA can regulate the metabolism and functions of circRNAs. Here we conducted this research to explore the patterns of m6A-methylation of circRNAs in the spinal cords of 4 morphine tolerated rats and 4 normal rats.吗啡耐受是一个棘手的科研问题，其具体分子机制目前仍未明确。环状RNA（Circular RNAs, CircRNAs）在中枢神经系统的生物学过程中发挥重要调控作用。N6-甲基腺苷（N6-methyladenosine, m6A）作为一种关键的RNA转录后修饰方式，可调控环状RNA的代谢与功能。本研究旨在探究4只吗啡耐受大鼠与4只正常大鼠脊髓组织中环状RNA的m6A甲基化修饰模式。