A voxel-based morphometry study of Tourette syndrome

We used T1-weighted MRI to compare brain structure in 15 adult TS volunteers and 15 carefully matched tic-free controls. No significant results after correction for multiple comparisons; trend decrease in GM concentration in voxels centered in left precentral gyrus (primary motor cortex) (-26, -12, 66). The official published abstract is available online at http://neuro.psychiatryonline.org/article.aspx?articleid=101807 Support: NARSAD, NINDS (NS41248, NS01898),<br>and the Charles A. Dana Foundation. We thank<br>the Tourette Syndrome Association for referral of<br>volunteers. More information: [e-mail]

我们采用T1加权磁共振成像（T1-weighted MRI），对15名成年图雷特综合征（Tourette Syndrome, TS）受试者与15名经过严格匹配的无抽动症状对照者的大脑结构进行对比分析。经多重比较校正后未发现显著结果；左侧中央前回（初级运动皮层）为中心的体素内，灰质（Gray Matter, GM）浓度呈下降趋势，该体素的坐标为(-26, -12, 66)。正式发表的研究摘要可在线获取于：http://neuro.psychiatryonline.org/article.aspx?articleid=101807。本研究得到NARSAD、美国国立神经病学与卒中研究所（NINDS, NS41248、NS01898）以及查尔斯·A·达纳基金会的资助。我们感谢图雷特综合征协会（Tourette Syndrome Association）为本次研究推荐受试者。更多信息请联系：[e-mail]