UGENE project_DATABASE_All participants.xlsx

Contribution of UCP1 single nucleotide
polymorphisms (SNPs) to susceptibility for cardiometabolic pathologies (CMP)
and their involvement in specific risk factors for these conditions varies
across populations. We tested whether UCP1 SNPs A-3826G, A-1766G,
Ala64Thr and A-112C are associated with common CMP and their risk factors
across Armenia, Greece, Poland, Russia and United Kingdom. This case-control
study included genotyping of these SNPs, from 2,283 Caucasians. Results were
extended via systematic review and meta-analysis. In Armenia, GA genotype and A
allele of Ala64Thr displayed ~2-fold higher risk for CMP compared to GG
genotype and G allele, respectively (p<0.05). In Greece, A allele of
Ala64Thr decreased risk of CMP by 39%. Healthy individuals with A-3826G GG genotype
and carriers of mutant allele of A-112C and Ala64Thr had higher body mass index
compared to those carrying other alleles. In healthy Polish, higher
waist-to-hip ratio (WHR) was observed in heterozygotes A-3826G compared to AA
homozygotes. Heterozygosity of A-112C and Ala64Thr SNPs was related to lower
WHR in CMP individuals compared to wild type homozygotes (p<0.05).
Meta-analysis showed no statistically significant odds-ratios across our SNPs
(p>0.05). Concluding, the studied SNPs could be associated with the most
common CMP and their risk factors in some populations.