Additional file 1 of The natural history of primary progressive multiple sclerosis: insights from the German NeuroTransData registry

Additional file 1: Figure S1. Time from first EDSS assessment at or after diagnosis to 48-week confirmed EDSS score of ≥4 at or after diagnosis Kaplan-Meier survival curve for DMT-naïve PPMS patients. Patients were censored at start of any DMT. Patients were considered at-risk until the last assessment visit recorded prior to data cut-off or censored at time of death or at start of any DMT whichever occurred first. Figure S2. Time from first EDSS assessment at or after diagnosis to 48-week confirmed EDSS score of ≥7 Kaplan-Meier survival curve for DMT-naïve PPMS patients. Patients were censored at start of any DMT. Patients were considered at-risk until the last assessment visit recorded prior to data cut-off or censored at time of death or at start of any DMT whichever occurred first. Figure S3. Time from first EDSS assessment at or after diagnosis to 48-week confirmed EDSS score of ≥4 Kaplan-Meier survival curve for subgroups of DMT naïve PPMS patients ≤55 and >55 years at the time of PPMS diagnosis. Patients were censored at start of any DMT. Patients were considered at-risk until the last assessment visit recorded prior to data cut-off or censored at time of death or at start of any DMT whichever occurred first. Figure S4. Time from first EDSS assessment at or after diagnosis to 48-week confirmed EDSS score of ≥7 Kaplan-Meier survival curve for subgroups of DMT-naïve PPMS patients ≤55 and >55 years at the time of PPMS diagnosis. Patients were censored at start of any DMT. Patients were considered at-risk until the last assessment visit recorded prior to data cut-off or censored at time of death or at start of any DMT whichever occurred first.