MRS CLEAN: A Synthetic Tabular Dataset of Stroke Patients based on the MR CLEAN Trials

MRS CLEAN This repository contains a synthetic tabular dataset of stroke patients based on the MR CLEAN Registry and MR CLEAN-LATE, MR CLEAN-MED and MR CLEAN-NOIV trials. We evaluated multiple synthetic data generation methods and found that TabDDPM works best, generating data that is statistically similar to the real data. On a functional outcome prediction task, prediction models trained on synthetic data show similar performance to models trained on real data when evaluating on a (real) held out test set. For more information on the development of the TabDDPM model, we refer to our preprint. Variable Codebook: Variable codename Human‑readable name Datatype Possible values Interpretation Distribution StudySubjectID Study subject identifier string S0000–S14999 Unique patient identifier n=15,000, all unique r_age Age (years) integer 25–93 Age at stroke onset 72 (64–81) r_sex Sex binary 0, 1 0 = male, 1 = female 0: 48.7%, 1: 51.3% bl_NIHSS_sumscore Baseline NIHSS score integer 0–42 National Institutes of Health Stroke Scale; stroke severity (higher = worse) 15 (11–20) bl_phy_rrsyst Baseline systolic blood pressure (mmHg) integer ~90–250 Systolic BP at baseline 150 (134–167) bl_phy_rrdiast Baseline diastolic blood pressure (mmHg) integer ~45–185 Diastolic BP at baseline 82 (73–91) bl_lab_glucose Baseline blood glucose (mmol/L) integer 1–100 Fasting or random glucose 7 (6–8) bl_hist_is Prior ischemic stroke binary 0, 1 0 = no, 1 = yes 0: 84.2%, 1: 15.8% bl_hist_ht Hypertension binary 0, 1 0 = no, 1 = yes 0: 48.5%, 1: 51.5% bl_hist_af Atrial fibrillation binary 0, 1 0 = no, 1 = yes 0: 78.6%, 1: 21.4% bl_hist_dm Diabetes mellitus binary 0, 1 0 = no, 1 = yes 0: 85.5%, 1: 14.5% bl_hist_mi Prior myocardial infarction binary 0, 1 0 = no, 1 = yes 0: 88.0%, 1: 12.0% bl_hist_pad Peripheral artery disease binary 0, 1 0 = no, 1 = yes 0: 93.5%, 1: 6.5% bl_hist_hc Hypercholesterolemia binary 0, 1 0 = no, 1 = yes 0: 72.4%, 1: 27.6% bl_hist_smoking Smoking status ordinal 0, 1, 2 0 = never, 1 = former, 2 = current 0: 62.1%, 1: 21.1%, 2: 16.8% bl_hist_premrs Pre-stroke modified Rankin Scale ordinal 0–5 Functional status before stroke; 0 = no symptoms, 5 = severe disability 0: 67.4%, 1: 16.0%, 2: 7.6%, 3: 5.5%, 4: 3.1%, 5: 0.4% bl_hist_apt Antiplatelet therapy at baseline binary 0, 1 0 = no, 1 = yes 0: 70.8%, 1: 29.2% bl_hist_hep Heparin at baseline binary 0, 1 0 = no, 1 = yes 0: 98.8%, 1: 1.2% bl_hist_ahtd Antihypertensive drugs at baseline binary 0, 1 0 = no, 1 = yes 0: 45.7%, 1: 54.3% bl_hist_stat Statins at baseline binary 0, 1 0 = no, 1 = yes 0: 65.8%, 1: 34.2% occlside_LeftRight Occlusion side categorical 1, 2, 3, 4 1 = left, 2 = right, 3 = both, 4 = unknown 1: 52.3%, 2: 47.4%, 3: 0.2%, 4: 0.03% bl_cta_prox_occl_loc_CatSAP Proximal occlusion location (CatSAP) categorical 0, 1, 2, 3, 4 0 = ICA, 1 = ICA‑T, 2 = M1 proximal, 3 = M1 distal, 4 = M2 0: 0.3%, 1: 4.2%, 2: 18.0%, 3: 58.4%, 4: 19.1% bl_ASPECTS Alberta Stroke Program Early CT Score ordinal 0–10 Early ischemic change on NCCT; higher = less damage; 10 = normal 10: 39.3%, 8: 19.4%, 9: 18.7%, 7: 11.2%, 6: 5.0%, 0–5: 6.4% collateral_grade Collateral grade on CTA ordinal 0, 1, 2, 3 0 = absent, 1 = poor, 2 = moderate, 3 = good 0: 4.3%, 1: 35.0%, 2: 40.7%, 3: 20.0% postetici_c Post-procedural eTICI score ordinal 0–5 Extended Thrombolysis in Cerebral Infarction; reperfusion grade 0: 13.1%, 1: 5.8%, 2: 17.6%, 3: 21.6%, 4: 10.1%, 5: 31.8% r_ivt Intravenous thrombolysis binary 0, 1, 9 0 = no, 1 = yes, 9 = missing/unknown 0: 35.5%, 1: 64.4%, 9: 0.1% TI.onsetlsw_to_groin Onset to groin puncture (minutes) integer ~38–1190 Time from last seen well to groin puncture 190 (131–249) deepest_anesthmanag Deepest anesthesia during procedure categorical 0, 1, 2, 3, 4 0 = conscious sedation, 1 = general anesthesia, 2–4 = other 0: 80.8%, 1: 19.0%, 2–4: 0.3% TI.groin_to_endproc Groin puncture to end of procedure (minutes) integer ~10–280 Procedure duration 55 (36–74) number_iat_attempts Number of intra-arterial thrombectomy attempts integer 0–17 Number of device passes 1 (0–2) balloon_used Balloon guide catheter used binary 0, 1 0 = no, 1 = yes 0: 44.6%, 1: 55.4% fu24h_NIHSS_sumscore NIHSS at 24 hours integer 0–42 Stroke severity at 24h follow-up 9 (3–15) sICH_HBC Symptomatic intracranial hemorrhage (Heidelberg) binary 0, 1 0 = no, 1 = yes; per Heidelberg Bleeding Classification 0: 95.3%, 1: 4.7% mrs_90d Modified Rankin Scale at 90 days ordinal 0–6 Primary outcome; 0 = no symptoms, 6 = death; mRS ≤2 = functional independence 0: 7.3%, 1: 15.2%, 2: 20.7%, 3: 13.9%, 4: 12.5%, 5: 6.6%, 6: 23.7% SAE_any Any serious adverse event binary 0, 1 0 = no, 1 = yes 0: 63.5%, 1: 36.5% SAE_strokeprog Stroke progression (SAE) binary 0, 1 0 = no, 1 = yes; neurological deterioration with imaging confirmation 0: 92.2%, 1: 7.8% SAE_pneu Pneumonia (SAE) binary 0, 1 0 = no, 1 = yes 0: 91.3%, 1: 8.7% Abbreviations NIHSS: National Institutes of Health Stroke Scale mRS: Modified Rankin Scale ASPECTS: Alberta Stroke Program Early CT Score CTA: Computed tomography angiography eTICI: Extended Thrombolysis in Cerebral Infarction sICH: Symptomatic intracranial hemorrhage SAE: Serious adverse event ICA: Internal carotid artery ICA‑T: Internal carotid artery terminus M1/M2: Middle cerebral artery segments Access Conditions Access to this dataset is granted on an individual basis. By requesting and receiving access, you agree to the following conditions: 1. No RedistributionYou may not share, distribute, upload, publish, sublicense, or otherwise provide the dataset—whether in full, in part, or in modified form—to any third party.This prohibition includes (but is not limited to) sharing via email, cloud services, repositories, supplementary materials, or public or private archives.' 2. Personal, Authorized Use OnlyAccess is granted only to the individual whose request is approved.You may not transfer your access or allow others to use your copy of the dataset. 3. Attribution RequirementAny publication or public output that uses or is derived from this dataset must include proper attribution (please use the citation at the right side of the page). References Pirson FAV, et al. MR CLEAN-LATE: a multicenter randomized clinical trial of endovascular treatment of acute ischemic stroke. Trials 2021;22:160. PMC7903604 von Kummer R, et al. The Heidelberg Bleeding Classification. Stroke 2015;46:2981–2986. Berkhemer OA, et al. A randomized trial of intraarterial treatment for acute ischemic stroke (MR CLEAN). N Engl J Med 2015;372:11–20.