Mice received an oral gavage of either leucine or vehicle, and quadriceps muscle were harvested for ribosome profiling or RNA-Seq analysis. Overall design: Gene expression analysis in the skeletal mus
PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1) is a newly identified family of Ser/Thr phosphatases that catalyzes the dephosphorylation of a conserved regulatory motif of the AGC ki
Mitochondria require thousands of proteins to fulfil their essential function in energy production and other fundamental biological processes. These proteins are mostly encoded by the nuclear genome,
SECIS binding protein 2 (SECISBP2) increases the efficiency of recoding of UGA codons as selenocysteine (Sec) during translation of mRNAs containing a selenocysteine insertion sequence (SECIS) in the
We describe the effects of knocking out the Secisbp2 and Trsp genes on selenoprotein expression and translation in mouse liver Overall design: Livers from wild type mice and mice that were deleted for
