Gene Expression Analysis of Nestin-creERT2, or NG2-creERTM driven P53f/f; Nf1f/+; Ptenf/+ mouse GBM

We have developed spontaneous genetically engineered GBM mouse models from two distinct cells of origin: subventricular zone neural stem cells (SVZ; Nestin-creERT2) and oligodendrocyte lineage progenitor cells (OPC; NG2-creERTM). These tumors are biologically separable and are reflective of their lineage of origin. Seven Nestin-creERT2 driven (Type 1) and Seven NG2-creERTM driven (Type 2) primary mouse tumors with consistant histology features were characterized by mRNA profiling in two different batches.