Liver Cullin 3 knockout transcriptomics

To investigate the liver transcriptomics of WT and liver Cullin 3 KO mice on chow diect (CD) and Westrn diet (WD) C57BL/6 Cul3 flox mice were on CD or WD for 13 weeks, then AAV-TBG-Null or AAV-TBG-Cre were injected to these mice to generate WT and liver Cul3 KO mice, respectively. Mice were maintained on the same diet (eitehr CD or WD) for additional 5 weeks and tissues were collected for analysis.