Gene expression profiles in rat alveolar macrophages exposure to submicron carbon fibers

To evaluate the biological effects at the transcriptional level of manufactured nanomaterials, whole genome microarrays of rat alveolar macrophages (NR8383) exposed to three types of submicron-diameter carbon fibers (SCFs) with different physicochemical properties were performed. In comparison with the fibers of SCF1, the fibers of SCF2 were shorter, and the fibers of SCF3 were thinner.为评估人工制备纳米材料在转录水平上的生物学效应，本研究对暴露于三种具有不同理化性质的亚微米直径碳纤维（SCFs）的大鼠肺泡巨噬细胞（NR8383）开展了全基因组微阵列分析。相较于SCF1型碳纤维，SCF2型碳纤维长度更短，SCF3型碳纤维直径更细。