Porphyromonas gingivalis aggravates colitis via the Gut microbiota Linoleic acid metabolism Th17 Treg balance axis

Porphyromonas gingivalis aggravates colitis via the gut microbiota linoleic acid (LA) metabolism Th17 Treg balance axis. Oral administration of Pg increased the Bacteroides phylum. Still, it suppressed the metabolite LA, the target metabolite that determined the degree of inflammation and functions as the AHR ligand to suppress Th17 differentiation but promote Treg differentiation via the phosphorylation of Stat1 at Ser727.