Negative correlation of Pax3:Foxo1 expression at the single-cell-level with tumorigenic potential in rhabdomyosarcoma
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE153894
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In mouse Myf6Cre,Pax3:Foxo1,p53 rhabdomyosarcoma (RMS) cells, expression of Pax3:Foxo1 (P3F) is directed by the Pax3 promoter and coupled to an eYFP fluorescent marker. YFPlow/P3Flow mouse RMS cells differentially expressed transcripts involved in extracellular matrix interaction, reorganized their actin cytoskeleton to promote adhesion/ migration and exhibited higher tumor-propagating capacity in limiting dilution analyses. Total RNA was isolated from YFPlow/P3Flow, YFPhigh/P3Fhigh and unfractionated low-passage mouse RMS cells (U23674) and analyzed by Clariom S Assays, mouse arrays (Affymetrix 902931).
创建时间：
2021-07-06
