A single amino acid substitution improves the in vivo immunogenicity of the HPV16 oncoprotein E7(11-20) cytotoxic T lymphocyte epitope.
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Immunization with the altered peptide ligand (YMLDLQPETV) of the naturally-occurring epitope (YMLDLQPETT) was shown to produce an enhanced CTL response against YMLDLQPETT compared to immunization with the naturally-occurring epitope. Similar results were obtained whether or not the effector cells were restimulated in vitro prior to the assay.
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IEDB创建时间：
2005-01-01
