Modified F75 formula for stabilisation among hospitalised children with severe acute malnutrition: double blind, randomised controlled trial

In a multi-centre double-blind trial, hospitalised severely malnourished children were randomised to receive standard formula (F75) or isocaloric modified F75 (mF75) without lactose and with reduced carbohydrate. The primary endpoint was time to stabilisation, as defined by the World Health Organisation, with intention-to-treat analysis. Secondary outcomes included in-hospital mortality, diarrhea, and biochemical features of malabsorption and refeeding syndrome. The trial was registered at clinicaltrials.gov (NCT02246296).