Cholesteryl Ester Transfer Protein (CETP) as a Drug Target for Cardiovascular Disease

Contains data and computer scripts to generate the figures underlying the manuscript: Cholesteryl Ester Transfer Protein (CETP) as a Drug Target for Cardiovascular Disease.<br>The README.md:# Scripts and deposited data <br>This directory contains R and python scripts along with the data necessary to generate the results described in the manuscript: 'cholesteryl ester transferprotein (CETP) as a drug target for cardiovascular disease'. <br>## Directory content <br>.├── README.md├── scripts├── figures├── MR_data├── TRIAL_data└── PICKLED_data<br>The `scripts` directory contains the computer codes necessary to generate the figures which get saved to the `figures` directory.<br>The scripts source data from the `MR_data` and `TRIAL_data` directories. The `PICKLED_data` directory contains the python pickled files from which we extracted the .csv files in `MR_data` -- these files can be ignored. <br>## Computer scripts<br>The directory root contains various R (.R) and python (.py) scripts that will process the data files. <br>It also contains a `cetp_conda_env.yml` file to conda install the necessary R and python modules:<br>```cd scriptsconda env create -f cetp_conda_env.yml ```<br>This creates the `cetp` conda environment. <br>To generate the figures, please run the following `bash` script:<br>```# run from the scripts directory./run_scripts.sh```<br>### Input and output<br>* scripts/MR_heatmap.py: Takes the MR_data .tsv files and returns Figures 2 and 5.* scripts/MR_metabolites.R: Takes the MR_data .tsv/csv files and returns Figure 4.* scripts/MR_forestplots.R: Takes the MR_data .tsv files and returns Figure 3.* scripts/RCT_forestplots.R: Takes the TRIAL_data .xlsx files and returns Figure 1.<br><br>## Contact<br>Please contact Floriaan Schmidt for any queries: [e-mail] . <br>