Regioselective Derivatizations of a Tribrominated Atropisomeric Benzamide Scaffold
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https://figshare.com/articles/dataset/Regioselective_Derivatizations_of_a_Tribrominated_Atropisomeric_Benzamide_Scaffold/2208829
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资源简介：
The
enantioselective synthesis of atropisomeric, tribrominated
benzamides and subsequent regioselective transformations to afford
derivatized, axially chiral molecules is reported. The enantioenriched
tribromides were carried through sequential Pd-catalyzed cross-coupling
and lithium–halogen exchange with high regioselectivity and
enantioretention. A variety of complexity-generation functional group
installations were performed to create a library of homochiral benzamides.
The potential utility of these molecules is demonstrated by using
a phosphino benzamide derivative as an asymmetric ligand in a Pd-catalyzed
allylic alkylation.
创建时间：
2016-02-15
