Simulations

The algorithm used to build the computer simulations was previously described elsewhere (Beltrame & Hughson, 2017a, 2017c). The simulated aVO2 time series response to an CWR and PRBS protocol (with a work rate variation between 25 and 100 watts) were built from the combinatorial analysis of the following parameters range: 10 < τ < 90 s (increment of 1 s) and 150 < steady state amplitude < 1650 ml·min-1 (every 75 ml·min-1). Each of these simulations was distorted by a white noise generator with a magnitude varying from 0 (without noise, for reference) to 450 ml·min-1 (every 5ml·min-1) resulting in 152,919 simulations with different aerobic system speeds, amplitudes and noise level, for each protocol (CWR and PRBS). The signal-to-noise of these simulations ranged from 0.3 to 330. Since τ, MNG, and CCFpeak are not influenced by baseline values, no baseline was added to the simulations. The τ range of these simulations was selected in order to include the same τ range of the experimental data (that was previously calculated).