Palladium-Catalyzed Regioselective Carbonylation of C–H Bonds of <i>N</i>‑Alkyl Anilines for Synthesis of Isatoic Anhydrides
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A Pd-catalyzed regioselective C–H bond carbonylation of N-alkyl anilines for the synthesis of isatoic anhydrides has been developed. The key Pd-catalyst intermediate has been isolated and characterized. This novel Pd-catalyzed carbonylation reaction tolerates a wide range of functional groups and is a reliable method for the rapid elaboration of readily available N-alkyl anilines into a variety of substituted isatoic anhydrides under mild conditions.
创建时间:
2016-02-20



