miR-106b-5p is a key player in adaptive response to drug-induced liver injury and liver regeneration by targeting vimentin

The key exosomal miRNAs in adaptive response to drug-induced liver (DILI) and liver regeneration were investigated and proved. This study aimed to decipher the mechanism of restorative events in the adaptive response to DILI by investigating circulating exosomal miRNAs. Using toosendanin-induced liver injury model, exosomal miR-106b-5p was identified as a robust driver in the adaptive response of TILI. Serum exosomal miRNAs were prepared on 3, 9, and 21 days of 80 mg/kg toosendanin exposure. Each group (TSN-3day，TSN-9day, TSN-21day, con-3day, can-9day, con-21day）contains 4 samples.