Table_2_A Voxel-Wise Meta-Analysis of Gray Matter Abnormalities in Essential Tremor.DOCX

Objective: To identify the consistent gray matter (GM) volume changes from the whole brain voxel-based morphometry (VBM) studies on essential tremor (ET).Methods: The whole brain VBM studies comparing ET patients and healthy controls (HCs) were systematically searched in the PubMed, Embase and Web of Science from January 2000 to December 2017. Coordinates with significant differences in regional GM volume between ET patients and HCs were extracted from included studies and the meta-analysis was performed using effect size-based signed differential mapping (ES-SDM).Results: A total of 10 studies with 241 ET patients and 213 HCs were included in the meta-analysis. The consistent GM volume reduction was detected in the left precuneus extending to the left posterior cingulate gyrus. The subgroup meta-analysis which included studies performed on a 3.0 T scanner revealed significant GM volume increases in the bilateral frontal lobes, bilateral temporal lobes, left insula, left striatum and left pons, but obvious publication biases of these findings were detected through funnel plots and Egger's tests.Conclusions: The consistent result of our meta-analysis showed a structural damage in the left precuneus extending to the left posterior cingulate gyrus, which possibly played a role in the cognitive dysfunction and depression in ET patients. It might enhance our understanding of the pathophysiological mechanisms underlying ET.

研究目标：旨在识别帕金森病（ET）患者全脑基于体素形态计量学（VBM）研究的持续灰质（GM）体积变化。研究方法：系统检索了PubMed、Embase和Web of Science数据库中2000年1月至2017年12月发表的全脑VBM研究，比较ET患者与健康对照者（HCs）。从纳入的研究中提取了ET患者与HCs之间区域GM体积差异显著的坐标，并采用基于效应量差异映射（ES-SDM）的元分析进行统计分析。研究结果：共纳入10项研究，涉及241名ET患者和213名HCs。在左侧颞叶延伸至左侧后扣带回区域检测到一致的GM体积减少。对在3.0T磁共振成像扫描仪上进行的子组元分析显示，双侧额叶、双侧颞叶、左侧岛叶、左侧纹状体和左侧脑桥的GM体积显著增加，但通过漏斗图和Egger检验检测到这些发现存在明显的发表偏倚。研究结论：我们的元分析的一致结果表明，左侧颞叶延伸至左侧后扣带回区域存在结构性损伤，这可能在ET患者的认知功能障碍和抑郁中发挥作用。这或许能加深我们对ET病理生理机制的理解。