Aqueous seeded RAFT polymerization for the preparation of self-assemblies containing nucleobase analogues [data]
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https://heidata.uni-heidelberg.de/citation?persistentId=doi:10.11588/data/U1O0NB
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资源简介：
Self-assemblies containing the nucleobase analogue 2,6-diacylaminopyridine (DAP) have been successfully prepared for the first time by aqueous seeded RAFT polymerization in high concentrations. For this purpose, a diblock copolymer containing poly(ethylene glycol) (PEG) and DAP polymethacrylate blocks was used as a macro-chain-transfer agent (PEG124-b-PDAP9-CTA) for the polymerization of 2-hydroxypropyl methacrylate (HPMA) in water. From the systematic variation of the degree of polymerization and solid concentration, a phase diagram has been generated that correlates both variables with the morphologies of this new system. Self-assemblies have been characterized by TEM and DLS, observing morphologies from low to high order (from spherical micelles to worms and to vesicles). Self-assembly morphologies are stable for almost a year, except in the case of worms that turn into spherical micelles after a few weeks. In addition, H-bonding supramolecular functionalization of the DAP repeating units during aqueous seeded RAFT polymerization has been examined by functionalization with a cross-linker with four thymine groups. Finally, the loading and the subsequent release of Nile Red have been proven in both supramolecular cross-linked and non-cross-linked self-assemblies.
提供机构：
, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen 76344, Germany); , CSIC-Universidad de Zaragoza, Zaragoza 50009, Spain; Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Zaragoza, Pedro Cerbuna, 12, Zaragoza 50009, Spain)
创建时间：
2023-01-01
