Monoclonal gammopathy of undetermined significance, NOS - Male, 69 - Tissue image [11290630017291571]

This is the histopathological image of HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 69Clinical description: A patient with normocytic anemia (Hgb - 9.0 g / dl), complaining of bone pain.
In additional tests:
hypercalcemia (3,5 mmol / l) and numerous osteolytic bone lesions in X-ray; monoclonal IgM lambda protein in the serum was found.Gender: MaleDiagnosis:Classification: ICD-O_3.2Classification code: IMMUNOPROLIFERATIVE DISEASESDiagnosis: Monoclonal gammopathy of undetermined significance, NOSResult of the histopathological examination: Monoclonal gammapathy of undetermined significance (MGUS)
Marrow with a cellularity of about 40%.
An average of 7% of the cellular marrow tissue are CD138 (+) / CD56 (-) / Kappa (+) / Lambda (+++) plasmocytes (kappa: lambda ratio equal to 1: 7).
Topography of the main lines of hemopoiesis is slightly disturbed , M: E ratio of 4: 1
Bone trabeculae without significant pathological changesSample:Material: FFPECollecting method: Bone marrow biopsyTopography: HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMSOrgan: HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMSTissue: Bone marrowType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk