Gene expression profiling during adhesion formation induced by cecum cauterization. Gene expression profiling during adhesion formation induced by cecum cauterization

Abdominal adhesions form in response to peritoneal trauma that can occur during surgery. Postoperative adhesions, which develop in approximately 50-85% of patients who have undergone abdominal surgery, often result in severe complications, including intestinal obstruction, female infertility, chronic pain, and contraindication of surgery for future abdominal illnesses such as cancer. Here, we investigated the cell source of collagen production in postoperative adhesions and explored molecular mechanisms of adhesion using microarray. Overall design: Transcriptional profiling of C57BL/6 mouse cecum tissues isolated at 3 different time points during adhesion formation, namely at 3 h, 12 h or 72 h after cauterization and the sham operation, was assessed using microarray analysis