The relationships between protein sequence, protein structure, protein function, and organismal fitness are key to understanding the molecular basis for the fitness effects of mutations. How protein p

NIAID Data Ecosystem70

Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease

靶点验证

深度突变扫描

This record contains supplementary data files related to Deep mutational scanning to characterize the mechanistic role of TYK2 in immune signaling and disease, described below. - tyk2.bcmap-final.

Zenodo2025-10-13 更新40

Engineering of the Ligand Specificity of Transcriptional Regulator XylS by Deep Mutational Scanning

蛋白质-配体相互作用

深度突变扫描

Deep mutational scanning is a method for protein engineering. Here, we applied it to alter the ligand specificity of the transcriptional regulator XylS from Pseudomonas putida to recognize p-toluic ac

NIAID Data Ecosystem100

SeprotHub/Dataset-RASH_HUMAN

蛋白质突变预测

深度突变扫描

该数据集包含了人类RASH蛋白质单点突变及其对应的突变效应分数，这些分数来自于深度突变扫描实验。蛋白质的格式为氨基酸序列。数据集分为训练集、验证集和测试集，分别包含2479、338和317个样本。标签表示基于深度突变扫描实验的每个蛋白质的突变效应分数，范围从负无穷大到正无穷大，其中0代表野生型的值，数值越大表示适应性越高。

Hugging Face2025-05-13 更新70

SDHA<sup>KO</sup> DMS pilot_96-108

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