Bicyclo[3.2.1]octane Synthons from Cyclopropenes: Functionalization of Cycloadducts by Nucleophilic Additions
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https://figshare.com/articles/dataset/Bicyclo_3_2_1_octane_Synthons_from_Cyclopropenes_Functionalization_of_Cycloadducts_by_Nucleophilic_Additions/3352339
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资源简介：
It has been known for several decades that a highly functionalized family of tetrahalobicyclo[3.2.1]octadienes are readily available through the cycloaddition of furan or cyclopentadiene with either
tetrachloro- or tetrabromocyclopropene. However, the application of these highly functionalized
building blocks in synthesis has remained relatively unexplored in relation to their better-known
counterparts derived through oxyallyl cation additions. As a first step toward utilizing these highly
versatile intermediates in synthesis, a study of the addition of various nucleophiles to the
halogenated nucleus has been conducted. It has been found that these halogenated systems are
amenable to a wide range of functionalizations in high yields and with good selectivities.
创建时间：
2004-01-23
