首页/数据集/VDAC2 ligands selectively and potently block BAK-mediated apoptosis to allow long-term clonogenic cell survival

VDAC2 ligands selectively and potently block BAK-mediated apoptosis to allow long-term clonogenic cell survival

NIAID Data Ecosystem2026-03-11 收录

细胞凋亡抑制

药物靶点鉴定

数据链接：

https://www.omicsdi.org/dataset/pride/PXD013129 数据链接链接失效反馈

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资源简介：

This study aimed to characterise the protein that a novel compound binds to, thus promoting its ability to inhibit BAK apoptotic activity.

应用场景：

创建时间：

2019-10-11

免疫学

细胞凋亡抑制

Background: Mast cells and basophils express the high-affinity IgE receptor, FcεRI, as well as the low-affinity IgG receptor, FcγRIIb. While FcεRI is responsible for IgE-dependent degran

DataCite Commons2020-09-02 更新80

β‑Lactones: A Novel Class of Ca 2+ -Independent Phospholipase A 2 (Group VIA iPLA 2 ) Inhibitors with the Ability To Inhibit β‑Cell Apoptosis

糖尿病药物靶点

细胞凋亡抑制

Ca2+-independent phospholipase A2 (GVIA iPLA2) has gained increasing interest recently as it has been recognized as a participant in biological processes underlying diabetes development and autoimmune

NIAID Data Ecosystem20

Nonmodified Strategy Enabled Proteome-Wide Mapping of Catechol Derivatives Interactome

儿茶酚衍生物相互作用组

药物靶点鉴定

Profiling the interactome of catechol derivatives plays a key role in revealing their pharmacology. Existing approaches for target identification generally rely on either the modification of ligands o

NIAID Data Ecosystem10

Venglustat Inhibits Protein N‑Terminal Methyltransferase 1 in a Substrate-Competitive Manner

药物靶点鉴定

酶抑制机制

Venglustat is a known allosteric inhibitor for ceramide glycosyltransferase, investigated in diseases caused by lysosomal dysfunction. Here, we identified venglustat as a potent inhibitor (IC50 = 0.42

NIAID Data Ecosystem40

TMT10_hela-ip-buf-pal_1_4_frag_ms2_140min.raw

化学蛋白质组学

药物靶点鉴定

hela treated with DMSO, Bufalin-photoaffinity probe, and Bufalin-photoaffinity probe competed with bufalin

Figshare2022-10-06 更新10