Effects of KNX-002 on T. gondii growth in culture and host cell viability/toxicity.

Tab A shows raw growth assay data, expressed in relative fluorescence units [RFU], of parasites grown in the presence of differing concentrations of KNX-002. Tab B shows the day 5 growth assay data expressed relative to average growth in an equivalent amount of DMSO; these numbers were used to calculate the compound’s IC50. The data in Tabs C and D show the results from CellTiter-Glo (panel C) and CellTox green (panel D) assays on HepG2 and HFF cells in the presence of 0 (DMSO vehicle only), 40, or 80 μM KNX-002. (XLSX)