Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Diaporthe sp.

A new sesquiterpenoid, diaporol A (1), possessing a unique tricyclic lactone framework, eight new drimane sesquiterpenoids, diaporols B–I (2–9), and the known compounds 10 and 11 were isolated from a culture of the mangrove-derived endophyte Diaporthe sp. The absolute configurations of 1–5 were determined by low-temperature (100 K) single-crystal X-ray diffraction with Cu Kα radiation. The compounds were evaluated for cytotoxic activity; however, no compound showed significant cytotoxicity against the tested cell lines at a concentration of 20 μM.一种新的二萜烯类化合物，二抱罗醇A（1），其具有独特的三环内酯结构框架，以及八种新的二抱罗烷类二萜烯化合物，二抱罗醇B–I（2–9），以及已知的化合物10和11，均从源于红树林内生真菌二抱罗菌属的菌种培养物中分离得到。化合物1至5的绝对构型通过低温（100K）单晶X射线衍射（Cu Kα辐射）进行确定。对这些化合物进行了细胞毒活性评估；然而，在20 μM的浓度下，无任何化合物对测试的细胞系表现出显著的细胞毒性。