Protective effect of total saponins from Panax ginseng C.A.Meyer cv. Silvatica against alcohol-induced colitis in mice based on gut microbiomics and metabolomics

As the primary barrier exposed to alcohol, the intestinal tract is a key target for alcohol-induced damage. Chronic alcohol intake was associated with intestinal barrier dysfunction, gut microbiota dysbiosis, and subsequent systemic inflammation. Panax ginseng C.A.Meyer cv. Silvatica exhibit multiple biological activities. The study aims to explore the protective effects of total saponins from Panax ginseng C.A.Meyer cv. Silvatica (TSG) on alcohol induced intestinal barrier damage and microbiota dysbiosis, with a focus on gut microbes and metabolites.