GNPS Streptomyces sp. BRA-346 _ NP3_MS_workflow case validation: proteasome inhibition candidate

Ethyl acetate extract from marine bacteria Streptomyces sp. BRA-346 have showed potent proteasome inhibition. This extract was submited to HPLC fractionation and a set of bioactive enriched fractions was selected to UPLC-MS/MS analysis. Obtained MS data was evaluated using NP3_MS_Workflow for predicting most probable m/z (M+H) candidates responsable for biological activity (proteasome inhibition).