Densification Profiles of Polyols

Pharmaceutically applicable polyols are represented by different grades of different chemical compounds with different bulk properties. Bulk properties, such as bulk and tap density, as well as densification kinetics, are very important characteristics for the handling, transportation, processing, as well as formulation and manufacturing of nutraceutical or pharmaceutical dosage forms (especially for tableting, capsuling, and putting into sachets). It is good practice to measure bulk density, tap density, and densification kinetics using pharmaceutically recognized methods.
Thus, project-related samples of commercially available polyols (such as sucrose, dextrin, inulin, xylitol, sorbitol, isomalt, and mannitol) were characterized with the pharmaceutically applicable method described below. The respective densification profiles were organized in a dataset.
Method. Densification kinetics of polyols was determined by the recording of the bulk and tapped density of the polyols. The experiment was performed using a tapped density tester (SVM II; Erweka GmbH, Langen, Germany). The measurements for samples were carried out using a 250 mL cylinder. Measurements were visually taken before any taps, after 10, 110, 1110, and 3110 taps. The equipment operated at a speed of 250 taps/min and a tapping height of 3 ± 0.2 mm. The measurements were carried out three times for each sample.
Data. The data in the form of a CSV spreadsheet was composed of the densification profiles of specific polyol grades: density (g/mL) vs. number of taps (file name: densification_profiles.csv). To simplify the reusing of data, densification profiles were presented in a graphical format (density, g/mL vs. number of taps, n; file name: Figure.jpg).