GNPS - Effects of light exposure on circulating metabolites in mice

The goal of this project is to identify metabolites released from subcutaneous adipose tissue due to light exposure that regulate systemic metabolism. We found that histidine levels increased by 8 days of blue light exposure, both in the treated subcutaneous adipose tissue and in circulation. Additionally, blue light-induced circulating histidine levels were not affected by the central blockade of histidine decarboxylase activity using FMH (Fluoromethylhistidine) in the hypothalamus. The details are described in the Summary Excel file.