CpG, CHH and CHG methylation in the control region of mitochondrial genome of dogs with malignant mammary gland tumours

This study aimed to evaluate its methylation status in CMT and its relation with the carcinogenesis process. We examined CpG, CHG and CHH methylation contexts in matched tumour and normal tissues from six German Shepherd dogs with histologically classified mammary carcinomas using enzymatic methyl-sequencing and high-throughput amplicon sequencing