RAF activation

This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>

此事件系通过对另一物种中已验证事件的计算推断得出。推断过程基于PANTHER的同源性映射。简而言之，对于所有涉及物理实体（包括输入、输出和催化剂）均具有映射同源/旁系同源物（对于复合物而言，至少75%的组成成分必须具备映射）的反应，将其推断至其他物种。此外，为了便于导航，对这些事件也进行了高级别事件的推断。<p>关于Reactome中事件推断的更多细节及注意事项，请参阅<a href='/electronic_inference_compara.html' target = 'NEW'>此处</a>。有关PANTHER的详细信息，请参阅<a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>。