Transcriptome response to KNL2 depletion in Arabidopsis

To analyze in more detail an effect of KNL2 mutation on expression of other genes in Arabidopsis, RNAseq experiments were performed for seedlings and flower buds of knl2 mutant and wild type. Analysis of the generated expression data has revealed a high number of genes differentially expressed in the knl2 mutant: ~1800 in flower buds and ~450 in seedlings, respectively. Among differentially expressed genes there are genes involved in regulation of the cell cycle, transcription and development as well as genes from the DNA repair pathway. Comprehensive information regarding the effects of KNL2 mutation on global gene expression and physiological changes in plants is presented, which provides an integrated understanding of the critical role for the KNL2 in plant growth and development.