Maternal inflammation promotes autoimmune susceptibility in offspring

NIAID Data Ecosystem2026-03-13 收录

母胎免疫交互

自身免疫疾病易感性

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE165720 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2022-01-19

Maternal Immune Activation perturbs fetal hematopoietic development and causes persistent changes to postnatal immunity [scRNA-Seq']

胎儿造血发育

母胎免疫交互

Adult hematopoietic stem cells (HSCs) respond directly to inflammation and infection, resulting in both acute and persistent changes in quiescence, mobilization, and differentiation. Here we show tha

NIAID Data Ecosystem40

Associations between TNF-α-308A/G Polymorphism and Susceptibility with Dermatomyositis: A Meta-Analysis

遗传关联研究

自身免疫疾病易感性

Background Some surveys had inspected the effects of the tumor necrosis factor-α (TNF-α)-308A/G polymorphism on susceptibility to dermatomyositis (DM), and showed mixed results. To briefly review thes

NIAID Data Ecosystem20

SNPs tagging SLE susceptibility loci with indication of their association in the study where they were discovered and in our current samples [16], [29], [30].

遗传关联分析

自身免疫疾病易感性

OR: Odds ratio. CI: confidence interval. aOnly women. The result for men in our samples was O.R. = 2.11 (1.3–3.4), P = 0.001. bOberved:Expected in transmission disequilibrium test.

NIAID Data Ecosystem10

Data_Sheet_1_Anti-IL6 Autoantibodies in an Infant With CRP-Less Septic Shock.docx

自身免疫疾病易感性

IL-6信号通路

Background: Interleukin-6 (IL-6) is a pleiotropic cytokine with a multitude of pro-inflammatory effects. Serum C-reactive protein (CRP) is an acute phase protein induced mainly by IL-6 in response to

NIAID Data Ecosystem30

自身免疫疾病易感性

病原体多样性

correlated with pathogen diversity which have been previously associated to susceptibility to autoimmune diseases.

NIAID Data Ecosystem20