Sex differences in RBM20 cardiomyopathy

In this study, we investigated potential sex differences in a Rbm20 knockout mouse model. We used RNA sequencing of bulk RNA from the left ventricle of male and female wildtype and Rbm20 knockout mice. 10-week old male and female wildtype and Rbm20 knockout mice were sacrificed, their hearts were harvested, and RNA from the LV was isolated and used for RNA sequencing.本研究针对Rbm20基因敲除小鼠模型中潜在的性别差异展开探究。我们采集了雄性与雌性野生型（wildtype）、Rbm20基因敲除小鼠的左心室批量RNA（bulk RNA），并对其开展RNA测序（RNA Sequencing）。本实验选取10周龄的雄性、雌性野生型及Rbm20基因敲除小鼠实施安乐死，采集其心脏组织，分离左心室（LV）中的RNA并用于RNA测序。