Data for investigation of cell-type-specific expression and regulation in Setbp1 (p.S858R) atypical SGS male mice

<strong>processed.tar.gz, contains all files from the data directory associated with this projects and includes the following:</strong> <strong>setbp1_targets.csv</strong> : list of human SETP1 gene targets from ChIP-seq experiments converted to mouse and enriched for additional interactions from literature references (https://pubmed.ncbi.nlm.nih.gov/35685777/ and https://www.nature.com/articles/s41467-018-04462-8, <strong>seurat_objects/</strong> <strong>kidney_integrated_celltypes.Rdata </strong>: filtered and preprocessed seurat object with cell type assignments for input to SoupX processing <strong>kidney_integrated_celltypes_postSoup.Rdata</strong> : preprocessed and quality controlled seurat object with final cell type assignments after SoupX processing <strong>setbp1_cerebralintcelltypes.Rdata</strong> : preprocessed and quality controlled seurat object with final cell type assignments <strong>decoupleR_CollecTRI/</strong> <strong>mouse_prior_tri.csv</strong> : accessed May 2023, it is unclear how versioning or accessions are used so we provided the Mouse CollecTRI (https://github.com/saezlab/CollecTRI) used in this study to calculate cell-type-specific TF activity <strong>motif_inputs/</strong> <strong>Mus_motif_all.txt </strong>: TF-motif PANDA input for mm10 reference genome enriched for <strong>expression_inputs/</strong> : expression matrices for all cell types for both tissues and conditions (n = 50) used to construct cell-type-specific PANDA networks <strong>The below files are from the data/results directory of this associated project and include the following:</strong> <strong>alpaca.tar.gz</strong> : directory containing differential community analysis outputs from ALPACA <strong>seurat.tar.gz </strong>: directory containing SoupX intermediates, as well as the