RORA proximal enhancer regulates its expression during early human Th17 cell differentiation

NIAID Data Ecosystem2026-05-02 收录

Th17细胞

增强子-基因调控

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE243064 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2024-05-24

Systems analysis of human T helper17 cell differentiation uncovers distinct time-regulated transcriptional modules

Th17细胞

免疫转录组

Th17 cells protect from infections and are pathogenic in autoimmunity. While human Th17 cell differentiation has been defined, the global and stepwise transcriptional changes accompanying this process

NIAID Data Ecosystem80

Reversing SKI–SMAD4-mediated suppression is essential for TH17 cell differentiation

Th17细胞

TGF-β信号通路

Disruption of Ski/Smad4 license Th17 differentiation. TGF-b-Ski-Smad4-RORgt-Th17 axis Examination of transcriptome under two different conditions (WT vs.Smad4 KO), two different treatment (Th0 and IL6

NIAID Data Ecosystem50

ASPSCR1-TFE3 reprograms transcription by organizing enhancers around hexameric VCP [RNA-Seq, FUUR1_KD]. ASPSCR1-TFE3 reprograms transcription by organizing enhancers around hexameric VCP [RNA-Seq, FUUR1_KD]

致癌融合基因

增强子-基因调控

ChIPseq experiments identify that ASPSCR1-TFE3 defines active enhancers across the genome and co-distributes with VCP/p97. RNAseq after knock-down of ASPSCR1-TFE3 or VCP, inhibition of VCP, or overexp

NIAID Data Ecosystem20

SUMOylation of ROR-gt inhibit IL-17 expression and inflamatiion

免疫调控分子

Th17细胞

RNA sequencing of ROR-gt-/- mouse-derived T cells reconstituted with either WT-ROR-gt or mutant (SUMOylation-defective ROR-gt) transcriptomic profiles of 4 WT and 4 mutant mice were analyzed using hig

NIAID Data Ecosystem60

IL-17 Induction by ArtinM is Due to Stimulation of IL-23 and IL-1 Release and/or Interaction with CD3 in CD4+ T Cells

Th17细胞

凝集素-免疫受体互作

ArtinM is a D-mannose-binding lectin extracted from the seeds of Artocarpus heterophyllus that interacts with TLR2 N-glycans and activates antigen-presenting cells (APCs), as manifested by IL-12 produ

Figshare2016-10-31 更新50

RORA proximal enhancer regulates its expression during early human Th17 cell differentiation

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