shRNA kinome screen identifies TBK1 as therapeutic target for HER2+ breast cancer

ChEBI2013-12-26 更新2026-07-21 收录

疾病靶点发现

HER2阳性乳腺癌

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-53658 数据链接链接失效反馈

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资源简介：

shRNA kinome screen identifies TBK1 as therapeutic target for HER2+ breast cancer

创建时间：

2013-12-26

PerturBench

单细胞扰动分析

疾病靶点发现

PerturBench是由Altos Labs开发的一个综合框架，旨在标准化细胞扰动分析领域的基准测试。该数据集包含多种扰动模式的数据，覆盖了化学和遗传扰动，以及组合扰动，数据量从数十万到数百万不等。数据集的创建过程涉及对现有数据集的筛选和预处理，以模拟真实世界的挑战。PerturBench主要应用于计算方法预测基因表达的扰动效应，旨在通过高吞吐量和高内容遗传及化学筛选，推动疾病靶点发现的研究。

arXiv2024-08-20 更新1570

DataSheet_1_Proteomic Analyses Identify Therapeutic Targets in Hepatocellular Carcinoma.xlsx

肝细胞蛋白质组学

疾病靶点发现

Hepatocellular carcinoma (HCC) is the fourth cause of cancer-related mortality worldwide. While many targeted therapies have been developed, the majority of HCC tumors do not harbor clinically actiona

NIAID Data Ecosystem50

Gene expression profiling of primary HER2-positive breast cancers before and after brief exposure to single agent neoadjuvant trastuzumab

HER2阳性乳腺癌

基因表达谱分析

Tumor incisional biopsies were obtained at baseline and after brief-exposure to single-agent trastuzumab from patients enrolled on the TRastuzumab-UPfront-in-HER2-positive-locally-advanced- BC (TRUP)

NIAID Data Ecosystem50

Drug screening and genomic analyses of HER2 positive breast cancer cell lines reveal predictors for treatment response [CGH]. Homo sapiens

HER2阳性乳腺癌

药物反应预测

Thirteen HER2 positive breast cancer cell lines were screened with 22 commercially available compounds, mainly targeting proteins in the ErbB2 signaling pathway, and the molecular mechanisms related t

NIAID Data Ecosystem80

YAP1 and PRDM14 converge to regulate cell survival and tumorigenesis

肿瘤发生机制

疾病靶点发现

The transcriptional co-activator YAP1 oncogene is the downstream effector of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration and tumorigenesis. Multiple cancers are dep

NIAID Data Ecosystem50

shRNA kinome screen identifies TBK1 as therapeutic target for HER2+ breast cancer

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