Antibodies studied in this work.

The second and third columns report the number of experimental IC50 values available as exact or approximate values. The fourth column reports the experimental breadth calculated based on the Seaman antigen panel. The number in parenthesis is the number of antigens used to calculate the breadth (the Seaman panel contains 109 antigens, but the experimental IC50 value is not available for all of them). The fifth column indicates the PDB ID used as the template for modeling the antibody/antigen complex. If only one PDB is indicated, that is used for the modeling “as is”. If two are present, the first is used to model the antibody, the second for the antigen (after best-fit RMSD superimposition to the antigen in the first PDB). The last three columns report the breadth calculated using the IC50 regressor with and without approximated values and using the IC50 classifier (see text).