Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2 mutant meningiomas in mice [human]
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https://www.ncbi.nlm.nih.gov/sra/SRP366301
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资源简介：
We analyzed the expression profiles of human and mouse meningiomas (driven by NF2 loss, YAP1-MAML2, TRAF7/KLF4/SMO1/AKT1, or constitutively active non-fusion YAP1). We found that YAP1-MAML2 meningiomas resemble NF2mutant tumors and constitutively exert de-regulated YAP1 activity that is dependent on the interaction with TEADs. Overall design: HEK 293 cells were grown in 48 well plates, transfected with indicated RCAS plasmids and total RNA was isolated 48 hours post-transfection
创建时间：
2022-09-12
