Type-III c-MET Inhibitor Enabled by Free-Energy Perturbation Calculations
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Type-III c-MET Inhibitor Enabled by Free-Energy Perturbation Calculations Descriptor: (1R,6M)-1-benzyl-6-[(3P)-3-(1-ethyl-1H-pyrazol-4-yl)-5-fluorophenyl]-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one, Hepatocyte growth factor receptor Authors: Eiler, D.R, Abraham, N, Kutter, S, Kroeck, K.G. Deposit date: 2026-02-25 Release date: 2026-05-27 Last modified: 2026-07-01 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Discovery of 2H-Pyrrolo[3,4‐ c ]pyridin-3-one Derivatives as Type-III c‐MET Inhibitors Enabled by Free-Energy Perturbation Calculations. Acs Med.Chem.Lett., 17, 2026
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2026-02-25
