Interaction of integrin alpha8beta1 with Tenascin-C

Tenascin-C (TN-C) and its isoforms are multidomain extracellular matrix (ECM) proteins that are believed to be involved in the regulation of stromal-epithelial interactions. Some of the interactions between TN-C and cells are mediated by integrins. Alpha8beta1 integrin interacts with the third FN type III repeats which contains an RGD sequence in tenascin-c.Tenascin-C (TN-C) 及其同种型为多结构域的细胞外基质 (ECM) 蛋白，据信参与调节基质-上皮细胞间的相互作用。TN-C 与细胞之间的某些相互作用由整合素介导。Alpha8beta1 整合素与含有 RGD 序列的 Tenascin-C 中的第三种 FN 类型 III 重复序列相互作用。