Supplementary Tables from Mutation Profiling of Key Cancer Genes in Primary Breast Cancers and Their Distant Metastases

Supplementary Table S1. Clinico-pathologic characteristics of primary breast cancers from our series and the METABRIC study and comparative analyses of the frequencies of somatic mutations found in the 341 genes analyzed. Supplementary Table S2. TP53 Sanger sequencing primers used in this study. Supplementary Table S3. Sequencing statistics Supplementary Table S4. Somatic mutations identified in 17 pairs of primary breast cancers and matched metastases using targeted massively parallel sequencing. Supplementary Table S5. Gene copy number alterations identified in the primary breast cancers and paired metastases. Supplementary Table S6. Pathway analyses of mutations and copy number aberrations that were enriched in metastases vs paired primary tumors per subtype Supplementary Table S7. Potentially targetable genetic alterations identified in primary breast cancers and matched metastases.