Excessive genomic instability coupled with abnormalities in DNA repair pathways induce high levels of “replication stress” when cancer cells propagate. Rather than hampering cancer cell proliferation,
Our study uncovers a distinct biomarker for MSI that underlies the synthetic lethal dependence on WRN, thereby supporting the development of WRN-based therapeutics ENDseq was performed under different
Mammalian SWI/SNF chromatin remodeling complexes exist in three distinct, final-form assemblies: canonical BAF (cBAF), PBAF, and a newly characterized non-canonical complex, ncBAF. However, their comp
