Crystal structure of the first bromodomain (BD1) of human BRD4 bound to GXH-II-052
收藏Protein Data Bank Japan2023-10-18 更新2026-04-19 收录
下载链接：
https://pdbj.org/mine/summary/7mr5
下载链接
链接失效反馈官方服务：
资源简介：
Crystal structure of the first bromodomain (BD1) of human BRD4 bound to GXH-II-052 Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N,N'-{oxybis[(ethane-2,1-diyl)oxy(1-oxoethane-2,1-diyl)piperidine-1,4-diyl]}bis{4-[(4-{4-chloro-3-[(2-methylpropane-2-sulfonyl)amino]anilino}-5-methylpyrimidin-2-yl)amino]-2-fluorobenzamide} Authors: Chan, A, Schonbrunn, E. Deposit date: 2021-05-07 Release date: 2022-05-18 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity. J.Med.Chem., 65, 2022
创建时间：
2021-05-07
