Summary of EC50s of concentration-response curves for L-Phe at different [Ca2+]o.
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The [Ca2+]i responses of HEK-293 cells transfected with CaSR or its mutants upon stepwise increases of L-Phe in the presence of 1.5 mM [Ca2+]o were recorded. For L173P and P221Q, the L-Phe induced intracellular change were also measured in the presence of a level of high [Ca2+]o corresponding to their EC50 values for the [Ca2+]o, specifically 15.0 mM [Ca2+]o for mutant L173P and 5.0 mM for P221Q. The results are shown in the brackets. The EC50s were calculated from the concentration-response curves fitted using the Hill equation. # indicates significance with respect to wild type CaSR, p* indicates significance with respect to the corresponding mutants in the presence of 1.5 mM [Ca2+]o, pSummary of EC50s of concentration-response curves for L-Phe at different [Ca2+]o.
创建时间：
2015-12-02
