Mechanistic insights into small-molecule inhibitor MS-444 arresting embryonic development revealed by low-input RNA-seq and dSTORM
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https://www.ncbi.nlm.nih.gov/sra/SRP352160
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资源简介：
The HuR small-molecule inhibitor MS-444 has been used in many cancer treatment studies, but its reproductive toxicity in females is unknown.Here, we used low-input RNA-seq and dSTORM to reveal the molecular mechanism and nanoscale organization changes by which MS-444 arrests embryonic development at the 2-cell stage. Overall design: Two groups [MS-444, DMSO] of embryos were examined, with three replicates in each group.
创建时间：
2023-09-21
