ATPint: Identification of ATP binding residues of a protein from its primary sequence

Welcome to the official repository for ATPint, a web server for predicting ATP-interacting residues in proteins from their primary sequence using Support Vector Machine (SVM) models. This resource is designed to support researchers in protein function annotation, structural biology, and computational drug discovery. Web Server: https://webs.iiitd.edu.in/raghava/atpint/ Citation Chauhan, J. S., Mishra, N. K., & Raghava, G. P. S. (2009). Identification of ATP binding residues of a protein from its primary sequence. BMC Bioinformatics, 10, 434. https://doi.org/10.1186/1471-2105-10-434 About the Tool ATPint is a web-based server for predicting residues in a protein that interact with the ATP ligand, using only the primary amino acid sequence as input. Adenosine-5'-triphosphate (ATP) is a critical coenzyme involved in membrane transport, muscle contraction, cellular motility, kinase-mediated phosphorylation, and regulation of metabolic processes. Identifying ATP-interacting residues experimentally is costly and time-consuming; ATPint provides a fast computational alternative. The method was developed using: 168 non-redundant ATP-binding protein (ABP) chains from PDB SVM models trained on binary sequence patterns and PSI-BLAST PSSM profiles Seven physico-chemical property scales as additional features Five-fold cross-validation for all performance evaluations